Clinical Trials

Vitiligo and the AMG 714

Vitiligo is an autoimmune illness in which T cells, which are part of your body’s immune system, assault melanocytes (the pigment producing cells in the skin). Patches of skin depigmentation result as a result of this (loss of normal skin color). Tissue resident memory T cells (Trm) are thought to be implicated in the attack on melanocytes, according to scientists. The chemical signal IL-15 is required for Trm cells to function. As a result, experts believe that disrupting the IL-15 signal may result in a decrease in Trm cells, which may help with vitiligo. AMG 714 is an investigational medication that inhibits IL-15, which may prevent the immune system from attacking melanocytes and allowing them to create normal skin color (repigmentation).

What information is required of participants?

– Participants will be randomized to one of two groups at random: The research medicine, AMG 714, will be given to one group, while the other will be given an inactive chemical termed a placebo.
– This study is double-blind, which means neither you nor your study doctor will know whether you are getting AMG 714 or a placebo during the study.
– The treatment lasts 12 weeks and includes six clinic visits and two subcutaneous injections every two weeks.
– The follow-up period is generally 36 weeks, with 5 clinic visits during that time.
– Participants may require Narrowband Ultraviolet B light (nbUVB) phototherapy treatment for approximately 24 weeks throughout the follow-up period, which will be supplied at no cost.

– You’ll get the active research medicine 2 out of every 3 times, and the placebo 1 out of every 3 times.

If you meet the following criteria, you may be eligible to participate in the REVEAL study:

– Are you between the ages of 18 and 75 years old?
– A dermatologist has diagnosed you with vitiligo.
– Have a visible amount of vitiligo on your face and body and are willing to discontinue alternative vitiligo treatments

Join Our Vitiligo Community

Are you dealing with a recent diagnosis or know someone who has vitiligo? We’re here to help you figure out what works best to manage symptoms and improve overall day-to-day life whether you or someone you love is affected.

Stay up-to-date on the latest news about treatments and managing symptoms. Sign up to get important email updates with relevant information.

This field is for validation purposes and should be left unchanged.