What is a Cultured Autograft

A cultured autograft is a tissue grown from one’s own skin cells for use in placing on the person’s own body. The Cultured Epithelial Autograft procedure involves amplification of the patient’s keratinocytes in vitro using a simple biopsy, and then employing them as a permanent epidermis to replace the afflicted skin area. CEAs allow a significant surface expansion, which cannot be achieved with other surgical techniques based on autologous grafting. Despite this, CEAs have a low take rate in full-thickness beds (i.e., muscle fascia) and persistently infected locations. Furthermore, the CEAs preparations that are now available are difficult to use. A neodermis will ultimately grow in the absence of a dermal bed, but giving allograft skin or a more permanent allodermis may boost clinical acceptance by minimizing infection and providing a viable dermal substitute.

The Downsides of Cultured Autografts

Some drawbacks with the use of cultured autografts are:

• Surgical procedure costs
• Limited quantity
• Donor site hypersensitivity

Some risks included with having a cultured autograft are:

• Graft failure
• Infection
• Sepsis
• Blister formation
• Graft tearing
• Skin tightening
• Increased risk for skin cancer

Instructions for patients choosing Cultured Autografts

• Bathe with mild soaps and moisturize with mild lotions
• Use pressure garments
• Minimize sun exposure to affected areas
• Apply sunscreen to any open areas
• Avoid tanning beds/sun lamps
• Avoid harmful chemicals

If you have noticed any abnormal changes in your skin, immediately see your healthcare provider.