Cultured Autografts

A cultured autograft is a tissue grown from one’s own skin cells for use in placing on the person’s own body


What is a Cultured Autograft

A cultured autograft is a tissue grown from one’s own skin cells for use in placing on the person’s own body. The Cultured Epithelial Autograft procedure involves amplification of the patient’s keratinocytes in vitro using a simple biopsy, and then employing them as a permanent epidermis to replace the afflicted skin area. CEAs allow a significant surface expansion, which cannot be achieved with other surgical techniques based on autologous grafting. Despite this, CEAs have a low take rate in full-thickness beds (i.e., muscle fascia) and persistently infected locations. Furthermore, the CEAs preparations that are now available are difficult to use. A neodermis will ultimately grow in the absence of a dermal bed, but giving allograft skin or a more permanent allodermis may boost clinical acceptance by minimizing infection and providing a viable dermal substitute.

The Downsides of Cultured Autografts

Some drawbacks with the use of cultured autografts are:

  • Surgical procedure costs
  • Limited quantity
  • Donor site hypersensitivity

Some risks included with having a cultured autograft are:

  • Graft failure
  • Infection
  • Sepsis
  • Blister formation
  • Graft tearing
  • Skin tightening
  • Increased risk for skin cancer

Instructions for patients choosing Cultured Autografts

  • Bathe with mild soaps and moisturize with mild lotions
  • Use pressure garments
  • Minimize sun exposure to affected areas
  • Apply sunscreen to any open areas
  • Avoid tanning beds/sun lamps
  • Avoid harmful chemicals

If you have noticed any abnormal changes in your skin, immediately see your healthcare provider.

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