Calcineurin Inhibitors

Calcineurin inhibitors are immune-modulating drugs that prevent the body’s immune system from attacking pigment-producing melanocytes. Calcineurin inhibitors are usually used when topical corticosteroids are ineffective or when vitiligo affects delicate parts of the skin that can’t be treated with them. The eyelids, lips, and genitals are among them.

 

Topical Calcineurin Inhibitors for Vitiligo

Calcineurin inhibitors are usually used when topical corticosteroids are ineffective or when vitiligo affects delicate parts of the skin that can’t be treated with them. The eyelids, lips, and genitals are among them. Topical calcineurin inhibitors are thought to help treat vitiligo by suppressing the disease’s autoimmune while simultaneously increasing melanocyte induction. Monotherapy with a topical calcineurin inhibitor appears to be effective, notably in youngsters and in lesions of the face and neck.

What are Calcineurin Inhibitors?

Calcineurin inhibitors are immune-modulating drugs that prevent the body’s immune system from attacking pigment-producing melanocytes. Calcineurin inhibitors are usually used when topical corticosteroids are ineffective or when vitiligo affects delicate parts of the skin that can’t be treated with them. The eyelids, lips, and genitals are among them.

Topical calcineurin inhibitors come in the form of a tacrolimus ointment or a pimecrolimus cream. These drugs are applied to the affected areas of skin once or twice a day and can take several months to take action. They are frequently part of a long-term therapy plan if they are beneficial.

For more than a decade, topical calcineurin inhibitors have been used safely. They have less long-term negative effects than corticosteroids and can be used for months or years with no problems. A stinging feeling may occur when first applied, however this usually subsides with time.

How does Calcineurin Inhibitors treat Vitiligo?

Topical calcineurin inhibitors come in the form of a tacrolimus ointment or a pimecrolimus cream. These drugs are applied to the affected areas of skin once or twice a day and can take several months to take action. They are frequently part of a long-term therapy plan if they are beneficial.

Research & Effectiveness of Calcineurin Inhibitors for Vitiligo

Topical tacrolimus and pimecrolimus are used to treat atopic dermatitis, but they’ve also been researched for a variety of other purposes. We looked at the English-language literature to see what role they play in vitiligo treatment. Tacrolimus 0.1 percent ointment mixed with excimer laser is superior to placebo in double-blind tests, especially for UV-resistant areas such bony prominences of the extremities. 

Tacrolimus 0.1 percent ointment is about as effective as clobetasol propionate 0.05 percent ointment when administered alone. It has also been shown in other studies to be effective for face lesions. Pimecrolimus 1% cream mixed with narrow band UVB is superior to placebo in double-blind tests, notably for face lesions. 

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